Example search terms: loss of pathogenicity, Candida, Enterococcus, Magnaporthe oryzae, wheat, azole, spot blotch disease, PHI:1020, ABC1, anti-infective
From mutant genes to phenotypes! The mission of PHI-base is to provide expertly curated molecular and biological information on genes proven to affect the outcome of pathogen-host interactions. Information is also given on the target sites of some anti-infective chemistries.
PHI-base data
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PHIB-BLAST
Find homologs and their phenotypes
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Manual curation of the pathogen interaction literature
PHI spotlight
October 2018
Ensembl refined their pipeline that imports data on host-pathogen interactions from PHI-base, improving the specificity. These data map PHI-base terms to genes, indicating how these genes are linked to phenotypes such as loss of pathogenicity or chemical sensitivity, which are involved in how the pathogen interacts with its host. We have PHI-base terms attached to genes in thousands of species in Ensembl Bacteria, Fungi and Protists. You can search for PHI-base terms in Ensembl, find them on genes and use them in BioMart. (http://www.ensembl.info/2018/10/08/ensembl-genomes-41-is-out/)
PHI-base is a National Capability funded by Biotechnology and Biological Sciences Research Council (BBSRC, UK) and is being developed and maintained by scientists at Rothamsted Research.
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