To utilise effectively the growing number of verified genes that mediate an organism's ability to cause disease and / or to trigger host responses, we have developed PHI-base.
This is a web-accessible database that catalogues experimentally verified pathogenicity, virulence and effector genes from fungal and Oomycete pathogens which infect animal, plant and fungal hosts. PHI-base is the first on-line resource devoted to the identification and presentation of information on fungal and Oomycete pathogenicity genes and their host interactions. As such, PHI-base is a strong valuable resource for the discovery of candidate targets in medically and agronomically important fungal and Oomycete pathogens for intervention with synthetic chemistries and natural products.
Each entry in PHI-base is curated by domain experts and supported by strong experimental evidence (gene disruption experiments) as well as literature references in which the experiments are described. Each gene in PHI-base is presented with its nucleotide and deduced amino acid sequence as well as a detailed structured description of the predicted protein's function during the host infection process. To facilitate data interoperability, we have annotated genes using controlled vocabularies (Gene Ontology terms, EC Numbers, etc.), and provide links to other external data sources (for example, NCBI taxonomy, EMBL and COGEME).